Brand: HPE | Category: Memory (RAM)
SKU: P67580-B21 | Part #: P67580-B21 | MPN: P67580-B21
Contact for Pricing — Request a Quote
The HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit (P67580-B21) delivers high-density, high-bandwidth memory capacity engineered for HPE ProLiant Gen11 and Compute Scale-Up servers. Built on the DDR5 architecture operating at 5600 MT/s, this kit provides substantial advances in raw memory bandwidth and power efficiency compared to prior DDR4 generations, enabling systems to sustain demanding parallel workloads without memory subsystem bottlenecks. Each 128GB Registered DIMM (RDIMM) leverages on-die ECC and advanced signal integrity features native to DDR5, supporting the reliability and data integrity requirements of mission-critical enterprise deployments.
HPE Smart Memory technology integrates an embedded Serial Presence Detect (SPD) with HPE-specific firmware, allowing the server platform to automatically identify, validate, and optimize memory configuration at boot. This intelligent interaction between the DIMM and the HPE Integrated Lights-Out (iLO) subsystem enables proactive health monitoring, memory fault isolation, and optimized performance tuning without manual intervention. The CAS-46 latency profile is calibrated for the 5600 MT/s operating frequency, balancing access latency against throughput for server-class workloads that require both.
At 512GB per kit, this memory solution is targeted at workloads requiring very large in-memory datasets, including in-memory databases, AI and machine learning model training and inference staging, large-scale virtualization hosts, and high-performance computing (HPC) environments. The registered (buffered) topology supports multi-rank addressing across the memory channel, making it suitable for high core-count processors that can drive substantial memory parallelism. This kit is validated and tested by HPE for compatibility within supported HPE server platforms, ensuring stable long-term operation in production datacenter environments.
| Manufacturer | HPE |
| Manufacturer Part Number | P67580-B21 |
| Kit Capacity | 512GB |
| DIMM Count per Kit | 4 |
| Capacity per DIMM | 128GB |
| Memory Technology | DDR5 |
| Speed | 5600 MT/s |
| CAS Latency | 46 (CL46) |
| DIMM Type | Registered DIMM (RDIMM) |
| Error Correction | ECC (On-Die ECC, DDR5 native) |
| Data Width | 80-bit (72-bit ECC) |
| Voltage | 1.1V |
| Form Factor | 288-pin DIMM |
| Memory Generation | DDR5 |
| HPE Smart Memory | Yes |
| Rank Configuration | Quad Rank (4Rx4) |
| Compatible Platform | HPE ProLiant Gen11 servers |
| RoHS Compliant | Yes |
Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.
| Brand | HPE |
| Category | Memory (RAM) |
| SKU | P67580-B21 |
| Part Number | P67580-B21 |
| Condition | New |
| Manufacturer Part Number | P67580-B21 |
| Kit Capacity | 512GB |
| DIMM Count per Kit | 4 |
| Capacity per DIMM | 128GB |
| Memory Technology | DDR5 |
| Speed | 5600 MT/s |
| CAS Latency | 46 (CL46) |
| DIMM Type | Registered DIMM (RDIMM) |
| Error Correction | ECC (On-Die ECC, DDR5 native) |
| Data Width | 80-bit (72-bit ECC) |
| Voltage | 1.1V |
| Form Factor | 288-pin DIMM |
| Memory Generation | DDR5 |
| HPE Smart Memory | Yes |
| Rank Configuration | Quad Rank (4Rx4) |
| Compatible Platform | HPE ProLiant Gen11 servers |
| RoHS Compliant | Yes |
Part number P67580-B21 is qualified for HPE servers that list compatible memory in their QVL. We verify QVL match before quoting — share your server model in the RFQ and our pre-sales engineers confirm fit, recommended population pattern, and total capacity supported.
Full manufacturer support (typically 3 years, RDIMM/LRDIMM SKUs often lifetime against manufacturing defects). All product is sourced through distribution so support registers cleanly under your company name.
Submit the RFQ form on this page with your quantity and destination country. Our pre-sales team responds with a vendor-confirmed quote, availability, and matching server-QVL confirmation if needed.