HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit

HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit

Brand: HPE | Category: Memory (RAM)

SKU: P67580-B21 | Part #: P67580-B21 | MPN: P67580-B21

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About the HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit

The HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit (P67580-B21) delivers high-density, high-bandwidth memory capacity engineered for HPE ProLiant Gen11 and Compute Scale-Up servers. Built on the DDR5 architecture operating at 5600 MT/s, this kit provides substantial advances in raw memory bandwidth and power efficiency compared to prior DDR4 generations, enabling systems to sustain demanding parallel workloads without memory subsystem bottlenecks. Each 128GB Registered DIMM (RDIMM) leverages on-die ECC and advanced signal integrity features native to DDR5, supporting the reliability and data integrity requirements of mission-critical enterprise deployments.

HPE Smart Memory technology integrates an embedded Serial Presence Detect (SPD) with HPE-specific firmware, allowing the server platform to automatically identify, validate, and optimize memory configuration at boot. This intelligent interaction between the DIMM and the HPE Integrated Lights-Out (iLO) subsystem enables proactive health monitoring, memory fault isolation, and optimized performance tuning without manual intervention. The CAS-46 latency profile is calibrated for the 5600 MT/s operating frequency, balancing access latency against throughput for server-class workloads that require both.

At 512GB per kit, this memory solution is targeted at workloads requiring very large in-memory datasets, including in-memory databases, AI and machine learning model training and inference staging, large-scale virtualization hosts, and high-performance computing (HPC) environments. The registered (buffered) topology supports multi-rank addressing across the memory channel, making it suitable for high core-count processors that can drive substantial memory parallelism. This kit is validated and tested by HPE for compatibility within supported HPE server platforms, ensuring stable long-term operation in production datacenter environments.

Ideal for

  • Large-scale AI and machine learning workloads requiring high-capacity in-memory staging of model parameters and training datasets
  • In-memory database platforms such as SAP HANA, Redis, or VoltDB where entire working datasets must reside in DRAM for low-latency access
  • High-density server virtualization environments running large numbers of memory-intensive virtual machines on HPE ProLiant Gen11 hosts
  • High-performance computing (HPC) clusters executing simulation, molecular dynamics, or computational fluid dynamics workloads with large memory footprints
  • Enterprise analytics and business intelligence platforms processing large datasets entirely in memory to minimize query response times
  • Cloud service provider infrastructure nodes requiring maximum memory capacity per socket to support multi-tenant workloads at scale

Technical specifications

ManufacturerHPE
Manufacturer Part NumberP67580-B21
Kit Capacity512GB
DIMM Count per Kit4
Capacity per DIMM128GB
Memory TechnologyDDR5
Speed5600 MT/s
CAS Latency46 (CL46)
DIMM TypeRegistered DIMM (RDIMM)
Error CorrectionECC (On-Die ECC, DDR5 native)
Data Width80-bit (72-bit ECC)
Voltage1.1V
Form Factor288-pin DIMM
Memory GenerationDDR5
HPE Smart MemoryYes
Rank ConfigurationQuad Rank (4Rx4)
Compatible PlatformHPE ProLiant Gen11 servers
RoHS CompliantYes

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandHPE
CategoryMemory (RAM)
SKUP67580-B21
Part NumberP67580-B21
ConditionNew
Manufacturer Part NumberP67580-B21
Kit Capacity512GB
DIMM Count per Kit4
Capacity per DIMM128GB
Memory TechnologyDDR5
Speed5600 MT/s
CAS Latency46 (CL46)
DIMM TypeRegistered DIMM (RDIMM)
Error CorrectionECC (On-Die ECC, DDR5 native)
Data Width80-bit (72-bit ECC)
Voltage1.1V
Form Factor288-pin DIMM
Memory GenerationDDR5
HPE Smart MemoryYes
Rank ConfigurationQuad Rank (4Rx4)
Compatible PlatformHPE ProLiant Gen11 servers
RoHS CompliantYes

Frequently Asked Questions about HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit

Is the HPE 512GB (4x128GB) DDR5-5600 CAS-46 Registered Smart Memory Kit compatible with my server?

Part number P67580-B21 is qualified for HPE servers that list compatible memory in their QVL. We verify QVL match before quoting — share your server model in the RFQ and our pre-sales engineers confirm fit, recommended population pattern, and total capacity supported.

What support applies to this memory module?

Full manufacturer support (typically 3 years, RDIMM/LRDIMM SKUs often lifetime against manufacturing defects). All product is sourced through distribution so support registers cleanly under your company name.

How do I request a quote?

Submit the RFQ form on this page with your quantity and destination country. Our pre-sales team responds with a vendor-confirmed quote, availability, and matching server-QVL confirmation if needed.