HPE ProLiant DL380 Gen10 Plus

Brand: HPE | Category: Servers

SKU: HPE-DL380-001 | Part #: P01661-B21 | MPN: P01661-B21

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Network connectivity forms the backbone of any modern data centre deployment, and the HPE ProLiant DL380 Gen10 Plus addresses this reality head-on with a thoughtful approach to I/O density. The server arrives with a standard embedded HPE Ethernet 1Gb 4-port 331i adapter, but its real strength lies in the available expansion—up to eight PCIe Gen4 slots allow administrators to scale network capacity without architectural compromises. Whether you need 25GbE, 40GbE, or even 100GbE connectivity for clustered workloads, the flexible LOM architecture and PCIe expansion options mean the P01661-B21 can grow alongside your network demands rather than becoming a bottleneck as your infrastructure scales.

At its core, the HPE ProLiant DL380 Gen10 Plus is built on the 3rd Generation Intel Xeon Scalable processor family, commonly known as Ice Lake. Dual-socket configuration supports up to 40 cores per processor—80 logical cores total when fully populated—which translates to substantial multi-threaded throughput for virtualisation, analytics, and mixed enterprise workloads. The 2U form factor packs this compute density into a standard 19-inch rack, making efficient use of colocation space while maintaining hot-plug accessibility for service technicians. For environments where density matters but you cannot sacrifice serviceability, this balance is precisely why network engineers and infrastructure architects continue to specify HPE equipment in EMEA and Asia-Pacific deployments.

Memory configuration is where the P01661-B21 demonstrates its versatility for modern workloads. Thirty-two DIMM slots support traditional DDR4-3200 RDIMM and LRDIMM modules, but the platform also qualifies Intel Optane PMem 200 persistent memory, pushing total addressable memory to 8TB. This capability is not marginal—for in-memory databases, high-frequency trading systems, and large-scale AI inference engines, the ability to address terabytes of fast, persistent storage directly from the CPU socket eliminates entire layers of I/O latency that traditional SAS or NVMe storage cannot overcome. Storage architects evaluating the DL380 Gen10 Plus often find that Optane qualification alone justifies the platform choice for latency-sensitive applications.

Storage expansion remains a fundamental consideration in any 2U platform, and HPE has engineered the DL380 Gen10 Plus to support up to 48 small-form-factor hot-plug drives in 2.5-inch bays. The onboard Smart Array P408i-a SR Gen10 controller provides hardware RAID acceleration, while optional P416ie-m and additional HBA options give you flexibility to pursue NVMe-dominant architectures or tiered storage strategies without rearchitecting the platform. The combination of dense drive bays, dual redundant hot-swap power supplies rated at up to 1800W, and redundant hot-plug fans means you can build highly available storage arrays without external enclosures—important when every rack unit affects TCO in shared colocation environments across the GCC region.

Management and security infrastructure round out a platform designed for enterprise rigour. HPE iLO 5 (Integrated Lights-Out 5) provides out-of-band management via RESTful API, enabling seamless integration with HPE OneView and third-party orchestration tools. The Silicon Root of Trust, Secure Boot, and runtime firmware validation protect against firmware-level attacks, while optional TPM 2.0 support satisfies compliance mandates in regulated industries. For sysadmins and security teams responsible for thousands of servers across multiple geographies, this layered approach to platform integrity reduces attack surface without imposing operational friction. The HPE ProLiant DL380 Gen10 Plus runs all major hypervisors and operating systems—VMware ESXi, Microsoft Windows Server, Red Hat Enterprise Linux, and SUSE Linux Enterprise Server—making workload portability straightforward across your installed base.

Deployment Scenarios & Technical Positioning

• Dual-socket Ice Lake with up to 80 cores delivers sustained throughput for virtualised enterprise applications, multi-tenant cloud platforms, and containerised microservices at scale
• Eight PCIe Gen4 expansion slots enable custom GPU, NVMe, or network adapter integration without compromising the embedded 4-port 1GbE baseline
• Up to 8TB addressable memory with Intel Optane PMem 200 support qualifies the platform for in-memory databases, real-time analytics, and low-latency AI inference workloads
• Forty-eight 2.5-inch hot-plug drive bays with optional P416ie-m controller support mixed-tier storage architectures—SAS for capacity, NVMe for performance—in a single 2U footprint
• HPE iLO 5 and OneView integration streamline fleet management, firmware updates, and automated remediation across data centre and edge deployments
• Redundant power, cooling, and storage subsystems with hot-plug serviceability reduce planned maintenance windows and support high-availability SLAs
• Broad OS and hypervisor compatibility—ESXi, Windows Server, RHEL, SUSE—ensures the P01661-B21 fits existing standardisation rather than forcing platform migration

Omnixon Global supplies the HPE ProLiant DL380 Gen10 Plus and complementary enterprise infrastructure to data centre operators, AI labs, and large-scale enterprises throughout the UAE, GCC, and beyond. Our regional expertise in server configuration, qualification testing, and rapid deployment means you work with a partner who understands your specific needs—whether you are building new capacity, refreshing aging infrastructure, or integrating advanced memory and storage tiers. Contact us for a detailed technical discussion and quotation on the P01661-B21 and related HPE systems.