HPE ProLiant DL380 Gen11 4x H100 PCIe GPU Server Configuration

HPE ProLiant DL380 Gen11 4x H100 PCIe GPU Server Configuration

Brand: HPE | Category: GPUs

SKU: P58148-B21 | Part #: P58148-B21 | MPN: P58148-B21

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About the HPE ProLiant DL380 Gen11 4x H100 PCIe GPU Server Configuration

The HPE ProLiant DL380 Gen11 4x H100 PCIe GPU Server Configuration (P58148-B21) is a purpose-built, high-density 2U rack server engineered to accelerate the most demanding AI training, inferencing, and HPC workloads in enterprise and hyperscale datacenter environments. Built on the Intel Xeon Scalable (4th Gen, codenamed Sapphire Rapids) processor platform and integrated with four NVIDIA H100 80GB PCIe GPUs, this configuration delivers exceptional parallel compute throughput underpinned by NVIDIA's Hopper architecture, including Transformer Engine support, FP8 precision, and NVLink capabilities where applicable.

The DL380 Gen11 chassis provides a proven, enterprise-hardened foundation with HPE's Accelerator platform support, offering PCIe Gen5 interconnects for maximum GPU-to-CPU bandwidth and DDR5 memory subsystem support. The server accommodates high-wattage GPU workloads through advanced thermal design, including HPE's direct liquid cooling readiness and intelligent power management, making it well suited for sustained, continuous operation in production AI environments. HPE's iLO 6 management controller provides deep hardware observability, remote management, and integration with HPE GreenLake and OneView management ecosystems.

Targeted at enterprise IT teams, national research institutions, financial services firms, and AI-native businesses across UAE, GCC, EMEA, and APAC regions, this configuration is optimized for large language model (LLM) fine-tuning and inference, generative AI application development, molecular dynamics simulation, seismic data processing, and real-time deep learning inference at scale. The combination of HPE's ProLiant reliability engineering and NVIDIA H100 PCIe compute density positions this system as a production-grade AI infrastructure cornerstone.

Ideal for

  • Large language model (LLM) fine-tuning and generative AI inference for enterprise AI platforms requiring sustained multi-GPU throughput
  • Deep learning training for computer vision, natural language processing, and recommendation systems in financial services and retail sectors
  • High-performance computing (HPC) simulations including computational fluid dynamics, molecular dynamics, and climate modeling in research institutions
  • Real-time AI inferencing pipelines for fraud detection, risk modeling, and algorithmic decision-making in banking and capital markets
  • Seismic interpretation and subsurface modeling workloads in energy and oil and gas industries requiring GPU-accelerated data processing
  • Sovereign AI datacenter buildouts in UAE and GCC regions requiring enterprise-supported, rack-ready GPU server infrastructure

Technical specifications

ManufacturerHPE
Manufacturer Part NumberP58148-B21
Product LineHPE ProLiant DL380 Gen11
Form Factor2U Rack Server
GPU Configuration4x NVIDIA H100 80GB PCIe
GPU ArchitectureNVIDIA Hopper (GH100)
GPU Memory per Card80 GB HBM2e
Total GPU Memory320 GB HBM2e
GPU InterfacePCIe Gen5
Processor SupportIntel Xeon Scalable 4th Generation (Sapphire Rapids), dual-socket
Memory TypeDDR5 RDIMM / LRDIMM
Memory Slots32 DIMM slots (16 per processor)
PCIe GenerationPCIe 5.0
Storage ControllerHPE Smart Array (MR Gen11 or SR Gen11 series)
NetworkHPE Ethernet adapters; OCP 3.0 slot supported
Management ControllerHPE iLO 6
Operating System SupportMicrosoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware vSphere
Power SupplyRedundant High Efficiency Power Supplies (Platinum or Titanium rated)
CoolingHigh-performance hot-plug fans; direct liquid cooling ready
SecurityHPE Silicon Root of Trust, Secure Boot, TPM 2.0 support
ChassisHPE ProLiant DL380 Gen11 2U chassis

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandHPE
CategoryGPUs
SKUP58148-B21
Part NumberP58148-B21
ConditionNew
Manufacturer Part NumberP58148-B21
Product LineHPE ProLiant DL380 Gen11
Form Factor2U Rack Server
GPU Configuration4x NVIDIA H100 80GB PCIe
GPU ArchitectureNVIDIA Hopper (GH100)
GPU Memory per Card80 GB HBM2e
Total GPU Memory320 GB HBM2e
GPU InterfacePCIe Gen5
Processor SupportIntel Xeon Scalable 4th Generation (Sapphire Rapids), dual-socket
Memory TypeDDR5 RDIMM / LRDIMM
Memory Slots32 DIMM slots (16 per processor)
PCIe GenerationPCIe 5.0
Storage ControllerHPE Smart Array (MR Gen11 or SR Gen11 series)
NetworkHPE Ethernet adapters; OCP 3.0 slot supported
Management ControllerHPE iLO 6
Operating System SupportMicrosoft Windows Server, Red Hat Enterprise Linux, SUSE Linux Enterprise Server, VMware vSphere
Power SupplyRedundant High Efficiency Power Supplies (Platinum or Titanium rated)
CoolingHigh-performance hot-plug fans; direct liquid cooling ready
SecurityHPE Silicon Root of Trust, Secure Boot, TPM 2.0 support
ChassisHPE ProLiant DL380 Gen11 2U chassis

Frequently Asked Questions about HPE ProLiant DL380 Gen11 4x H100 PCIe GPU Server Configuration

What server platforms accept the HPE ProLiant DL380 Gen11 4x H100 PCIe GPU Server Configuration?

Reference servers include Dell PowerEdge XE9680 / XE9712, HPE Cray XD670, Lenovo ThinkSystem SR685a / SR675 V3, Supermicro AS-A21GE / SYS-821GE, Gigabyte G593 / G894, ASUS ESC. Share your target platform in the RFQ and we will confirm chassis-to-GPU compatibility and recommended NIC pairing.

How long is the lead time on AI GPUs?

Highly model-dependent. L40S / RTX-class: typically 3-6 weeks. H100/H200/B200 in SXM form factor: 12-16 weeks for whole-platform allocations. We quote genuine-channel ETAs only — no grey-market promises.

Do you supply matched networking (Quantum InfiniBand / Spectrum-X)?

Yes — Omnixon stocks the full NVIDIA networking lineup (Quantum-2 / Quantum-X InfiniBand, Spectrum-X Ethernet, ConnectX NICs, BlueField DPUs) so we can quote a complete training-cluster BOM, not just the GPUs.

Can you help with NVIDIA AI Enterprise licensing?

Yes. We hold genuine-channels for NVIDIA AI Enterprise software subscriptions. Add it to your RFQ and we quote node-aligned licensing along with the hardware.