Brand: HPE | Category: Memory (RAM)
SKU: P43333-B21 | Part #: P43333-B21 | MPN: P43333-B21
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The HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory (P43333-B21) is a high-capacity Load-Reduced DIMM engineered for HPE ProLiant Gen11 servers, delivering DDR5-4800 MHz performance across an eight-rank, quad-die-per-package architecture. Operating on the DDR5 standard at a base speed of 4800 MT/s, this module leverages an on-DIMM data buffer to reduce the electrical load on the memory controller, enabling platforms to populate higher DIMM counts per channel without sacrificing signal integrity or memory bandwidth.
As an HPE SmartMemory module, P43333-B21 incorporates an embedded Serial Presence Detect (SPD) EEPROM that stores HPE-validated firmware, allowing HPE ProLiant servers to authenticate the module at POST. This authentication unlocks full platform-level performance optimisation, Advanced Memory Protection features, and enhanced RAS (Reliability, Availability, and Serviceability) capabilities including ECC. The SmartMemory identification mechanism also enables proactive health monitoring through HPE iLO, surfacing memory health telemetry directly within the server management interface.
With a 256 GB single-module capacity, this LRDIMM is positioned for memory-intensive enterprise workloads where aggregate system memory must reach multiple terabytes per node. Data-heavy applications including in-memory databases, large-scale virtualisation environments, AI/ML model training, and high-performance analytics benefit directly from the combination of DDR5 bandwidth, deep buffering, and the high per-slot capacity this module provides. Its design aligns with HPE's validated memory population guidelines for Gen11 platforms, ensuring system-level stability under continuous production loads.
| Manufacturer | HPE |
| HPE Part Number | P43333-B21 |
| Module Type | LRDIMM (Load-Reduced DIMM) |
| Capacity | 256 GB |
| DDR Generation | DDR5 |
| Speed Grade | PC5-4800B-L |
| Data Transfer Rate | 4800 MT/s |
| Rank Configuration | 8Rx4 (8-Rank, x4 organization) |
| Error Correction | ECC (Error-Correcting Code) |
| Voltage | 1.1 V |
| Form Factor | 288-pin DIMM |
| SmartMemory | Yes — HPE authenticated SmartMemory with SPD EEPROM validation |
| Compatible Server Generation | HPE ProLiant Gen11 |
| RAS Features | Advanced ECC, memory health monitoring via HPE iLO |
| Operating Temperature | 0°C to 85°C (standard JEDEC DDR5 LRDIMM operating range) |
Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.
| Brand | HPE |
| Category | Memory (RAM) |
| SKU | P43333-B21 |
| Part Number | P43333-B21 |
| Condition | New |
| HPE Part Number | P43333-B21 |
| Module Type | LRDIMM (Load-Reduced DIMM) |
| Capacity | 256 GB |
| DDR Generation | DDR5 |
| Speed Grade | PC5-4800B-L |
| Data Transfer Rate | 4800 MT/s |
| Rank Configuration | 8Rx4 (8-Rank, x4 organization) |
| Error Correction | ECC (Error-Correcting Code) |
| Voltage | 1.1 V |
| Form Factor | 288-pin DIMM |
| SmartMemory | Yes — HPE authenticated SmartMemory with SPD EEPROM validation |
| Compatible Server Generation | HPE ProLiant Gen11 |
| RAS Features | Advanced ECC, memory health monitoring via HPE iLO |
| Operating Temperature | 0°C to 85°C (standard JEDEC DDR5 LRDIMM operating range) |
Part number P43333-B21 is qualified for HPE servers that list compatible memory in their QVL. We verify QVL match before quoting — share your server model in the RFQ and our pre-sales engineers confirm fit, recommended population pattern, and total capacity supported.
Full manufacturer support (typically 3 years, RDIMM/LRDIMM SKUs often lifetime against manufacturing defects). All product is sourced through distribution so support registers cleanly under your company name.
Submit the RFQ form on this page with your quantity and destination country. Our pre-sales team responds with a vendor-confirmed quote, availability, and matching server-QVL confirmation if needed.