HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory

HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory

Brand: HPE | Category: Memory (RAM)

SKU: P43333-B21 | Part #: P43333-B21 | MPN: P43333-B21

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About the HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory

The HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory (P43333-B21) is a high-capacity Load-Reduced DIMM engineered for HPE ProLiant Gen11 servers, delivering DDR5-4800 MHz performance across an eight-rank, quad-die-per-package architecture. Operating on the DDR5 standard at a base speed of 4800 MT/s, this module leverages an on-DIMM data buffer to reduce the electrical load on the memory controller, enabling platforms to populate higher DIMM counts per channel without sacrificing signal integrity or memory bandwidth.

As an HPE SmartMemory module, P43333-B21 incorporates an embedded Serial Presence Detect (SPD) EEPROM that stores HPE-validated firmware, allowing HPE ProLiant servers to authenticate the module at POST. This authentication unlocks full platform-level performance optimisation, Advanced Memory Protection features, and enhanced RAS (Reliability, Availability, and Serviceability) capabilities including ECC. The SmartMemory identification mechanism also enables proactive health monitoring through HPE iLO, surfacing memory health telemetry directly within the server management interface.

With a 256 GB single-module capacity, this LRDIMM is positioned for memory-intensive enterprise workloads where aggregate system memory must reach multiple terabytes per node. Data-heavy applications including in-memory databases, large-scale virtualisation environments, AI/ML model training, and high-performance analytics benefit directly from the combination of DDR5 bandwidth, deep buffering, and the high per-slot capacity this module provides. Its design aligns with HPE's validated memory population guidelines for Gen11 platforms, ensuring system-level stability under continuous production loads.

Ideal for

  • Large-scale virtualisation hosts running dense VM populations on HPE ProLiant Gen11 two-socket servers, where maximising total addressable memory per node is critical to consolidation ratios
  • In-memory database deployments such as SAP HANA or Redis Enterprise, where multi-terabyte memory configurations must sustain high-throughput transactional and analytical operations simultaneously
  • AI and machine learning inference or training nodes that require large model footprints to reside entirely in DRAM, reducing latency from storage-tier memory tiering
  • High-performance computing clusters and scientific simulation workloads demanding high aggregate memory bandwidth and large per-node memory capacity across tightly coupled parallel jobs
  • Enterprise private cloud infrastructure platforms where workload density, live-migration headroom, and memory overcommit ratios depend on maximum per-server DRAM population
  • Columnar analytics and data warehousing appliances processing large datasets entirely in-memory to deliver sub-second query response times across business intelligence platforms

Technical specifications

ManufacturerHPE
HPE Part NumberP43333-B21
Module TypeLRDIMM (Load-Reduced DIMM)
Capacity256 GB
DDR GenerationDDR5
Speed GradePC5-4800B-L
Data Transfer Rate4800 MT/s
Rank Configuration8Rx4 (8-Rank, x4 organization)
Error CorrectionECC (Error-Correcting Code)
Voltage1.1 V
Form Factor288-pin DIMM
SmartMemoryYes — HPE authenticated SmartMemory with SPD EEPROM validation
Compatible Server GenerationHPE ProLiant Gen11
RAS FeaturesAdvanced ECC, memory health monitoring via HPE iLO
Operating Temperature0°C to 85°C (standard JEDEC DDR5 LRDIMM operating range)

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandHPE
CategoryMemory (RAM)
SKUP43333-B21
Part NumberP43333-B21
ConditionNew
HPE Part NumberP43333-B21
Module TypeLRDIMM (Load-Reduced DIMM)
Capacity256 GB
DDR GenerationDDR5
Speed GradePC5-4800B-L
Data Transfer Rate4800 MT/s
Rank Configuration8Rx4 (8-Rank, x4 organization)
Error CorrectionECC (Error-Correcting Code)
Voltage1.1 V
Form Factor288-pin DIMM
SmartMemoryYes — HPE authenticated SmartMemory with SPD EEPROM validation
Compatible Server GenerationHPE ProLiant Gen11
RAS FeaturesAdvanced ECC, memory health monitoring via HPE iLO
Operating Temperature0°C to 85°C (standard JEDEC DDR5 LRDIMM operating range)

Frequently Asked Questions about HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory

Is the HPE 256GB 8Rx4 PC5-4800B-L LRDIMM SmartMemory compatible with my server?

Part number P43333-B21 is qualified for HPE servers that list compatible memory in their QVL. We verify QVL match before quoting — share your server model in the RFQ and our pre-sales engineers confirm fit, recommended population pattern, and total capacity supported.

What support applies to this memory module?

Full manufacturer support (typically 3 years, RDIMM/LRDIMM SKUs often lifetime against manufacturing defects). All product is sourced through distribution so support registers cleanly under your company name.

How do I request a quote?

Submit the RFQ form on this page with your quantity and destination country. Our pre-sales team responds with a vendor-confirmed quote, availability, and matching server-QVL confirmation if needed.