ASUS ESC4000A-E12 H200 PCIe 141GB GPU Server (4-GPU AMD EPYC)

ASUS ESC4000A-E12 H200 PCIe 141GB GPU Server (4-GPU AMD EPYC)

Brand: ASUS | Category: GPUs

SKU: ESC4000A-E12-H200 | Part #: ESC4000A-E12-H200 | MPN: ESC4000A-E12-H200

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About the ASUS ESC4000A-E12 H200 PCIe 141GB GPU Server (4-GPU AMD EPYC)

The ASUS ESC4000A-E12 is a 4U rack server engineered for high-density GPU compute, configured here with an NVIDIA H200 NVL PCIe GPU delivering 141 GB of HBM3e memory. Built on the AMD EPYC (Genoa) platform, the system supports dual 4th Gen AMD EPYC processors with up to 192 cores total and integrates a PCIe 5.0 fabric to maximize bandwidth between CPUs and GPU accelerators. The architecture is optimized for throughput-intensive AI inference, large-scale model training, and scientific simulation workloads that demand extreme memory capacity and bandwidth.

The ESC4000A-E12 accommodates up to four full-length, full-height dual-slot PCIe 5.0 x16 GPU cards, enabling multi-GPU parallelism within a single chassis without NVLink. The server supports high-capacity DDR5 RDIMM/LRDIMM memory across 24 DIMM slots, and provides extensive NVMe and SATA storage options through its onboard and riser-based storage connectivity. Dual 10GbE LAN ports and an optional OCP 3.0 network expansion slot ensure flexible high-speed networking for cluster and fabric integration. A 2000 W redundant platinum-rated power subsystem sustains continuous GPU and CPU operation under sustained compute loads.

Positioned for enterprise datacenters, cloud service operators, and AI research facilities across UAE, GCC, EMEA, and APAC regions, the ESC4000A-E12 H200 configuration addresses deployments where on-premises GPU density, memory footprint, and PCIe-native flexibility are prioritized over proprietary interconnects. The platform is compatible with major AI frameworks, HPC middleware, and virtualization stacks, making it a versatile foundation for diverse accelerated computing infrastructure.

Ideal for

  • Large language model (LLM) inference serving requiring 141 GB HBM3e memory capacity per GPU to run multi-hundred-billion parameter models without quantization
  • Generative AI training runs on mid-scale models using PCIe-attached multi-GPU parallelism within a single 4U chassis
  • High-performance computing (HPC) simulations in climate modeling, computational fluid dynamics, and molecular dynamics that benefit from HBM3e bandwidth
  • Enterprise AI inference clusters deployed on-premises in datacenter environments across GCC and EMEA requiring certified server platforms
  • Data analytics and GPU-accelerated database query acceleration leveraging large HBM3e memory to keep working datasets fully in-GPU memory
  • AI model fine-tuning and research experimentation workloads that require flexible PCIe GPU configurations without proprietary interconnect constraints

Technical specifications

ManufacturerASUS
Manufacturer Part NumberESC4000A-E12-H200
Form Factor4U Rack Server
CPU SupportDual 4th Gen AMD EPYC (Genoa) processors
CPU SocketSocket SP5 x2
Memory Slots24 x DDR5 DIMM slots
Memory TypeDDR5 RDIMM / LRDIMM
GPU Slots4 x PCIe 5.0 x16 full-length full-height dual-slot
Installed GPU1 x NVIDIA H200 NVL PCIe
GPU Memory141 GB HBM3e
GPU InterfacePCIe 5.0 x16
Storage Bays12 x 3.5-inch SATA/SAS hot-swap bays
NVMe SupportFront-accessible NVMe drives via PCIe 5.0
Network2 x 10GbE (Intel) onboard; 1 x OCP 3.0 expansion slot
ManagementIPMI 2.0, ASUS ASMB11-iKVM (dedicated management port)
Power Supply2 x 2000 W 80 PLUS Platinum redundant PSU
Expansion SlotsPCIe 5.0 x16 GPU riser slots; OCP 3.0 slot
Operating System SupportWindows Server, Ubuntu, Red Hat Enterprise Linux, VMware vSphere

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandASUS
CategoryGPUs
SKUESC4000A-E12-H200
Part NumberESC4000A-E12-H200
ConditionNew
Manufacturer Part NumberESC4000A-E12-H200
Form Factor4U Rack Server
CPU SupportDual 4th Gen AMD EPYC (Genoa) processors
CPU SocketSocket SP5 x2
Memory Slots24 x DDR5 DIMM slots
Memory TypeDDR5 RDIMM / LRDIMM
GPU Slots4 x PCIe 5.0 x16 full-length full-height dual-slot
Installed GPU1 x NVIDIA H200 NVL PCIe
GPU Memory141 GB HBM3e
GPU InterfacePCIe 5.0 x16
Storage Bays12 x 3.5-inch SATA/SAS hot-swap bays
NVMe SupportFront-accessible NVMe drives via PCIe 5.0
Network2 x 10GbE (Intel) onboard; 1 x OCP 3.0 expansion slot
ManagementIPMI 2.0, ASUS ASMB11-iKVM (dedicated management port)
Power Supply2 x 2000 W 80 PLUS Platinum redundant PSU
Expansion SlotsPCIe 5.0 x16 GPU riser slots; OCP 3.0 slot
Operating System SupportWindows Server, Ubuntu, Red Hat Enterprise Linux, VMware vSphere

Frequently Asked Questions about ASUS ESC4000A-E12 H200 PCIe 141GB GPU Server (4-GPU AMD EPYC)

What server platforms accept the ASUS ESC4000A-E12 H200 PCIe 141GB GPU Server (4-GPU AMD EPYC)?

Reference servers include Dell PowerEdge XE9680 / XE9712, HPE Cray XD670, Lenovo ThinkSystem SR685a / SR675 V3, Supermicro AS-A21GE / SYS-821GE, Gigabyte G593 / G894, ASUS ESC. Share your target platform in the RFQ and we will confirm chassis-to-GPU compatibility and recommended NIC pairing.

How long is the lead time on AI GPUs?

Highly model-dependent. L40S / RTX-class: typically 3-6 weeks. H100/H200/B200 in SXM form factor: 12-16 weeks for whole-platform allocations. We quote genuine-channel ETAs only — no grey-market promises.

Do you supply matched networking (Quantum InfiniBand / Spectrum-X)?

Yes — Omnixon stocks the full NVIDIA networking lineup (Quantum-2 / Quantum-X InfiniBand, Spectrum-X Ethernet, ConnectX NICs, BlueField DPUs) so we can quote a complete training-cluster BOM, not just the GPUs.

Can you help with NVIDIA AI Enterprise licensing?

Yes. We hold genuine-channels for NVIDIA AI Enterprise software subscriptions. Add it to your RFQ and we quote node-aligned licensing along with the hardware.