HPE ProLiant ML350 Gen11 Tower Server

HPE ProLiant ML350 Gen11 Tower Server

Brand: HPE | Category: Servers

SKU: P53566-B21 | Part #: P53566-B21 | MPN: P53566-B21

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About the HPE ProLiant ML350 Gen11 Tower Server

The HPE ProLiant ML350 Gen11 is a 2-socket tower server platform engineered for compute-intensive workloads in mid-market and departmental enterprise environments. Built on third-generation EPYC processor architecture, it supports up to 32 DIMM slots with ECC memory, delivering 12-core to 16-core per-socket configurations with up to 12 TFLOPS of peak floating-point performance. The tower form factor enables flexible placement in distributed office and lab environments while maintaining enterprise-class reliability and manageability.

The system accommodates up to eight 3.5-inch hot-swap SAS/SATA drives or six 2.5-inch SFF drives via integrated RAID controllers, with PCIe 5.0 expansion slots supporting GPU acceleration, storage adapters, and network interface cards. Integrated Intelligent Platform Management Interface (IPMI) and Redfish support enable remote out-of-band administration across heterogeneous IT estates.

Gen11 architecture introduces improved thermal efficiency and power delivery to sustained multi-threaded workloads, making the ML350 suitable for engineering simulation, data analytics, visualization-class render nodes, and virtualization host deployments requiring moderate scale and on-premises presence.

Ideal for

  • Engineering CAD/CAM simulation and finite element analysis on departmental compute clusters
  • Virtualization host for SMB private cloud and containerized application platforms requiring ECC memory
  • Machine learning model training and inference on GPU-accelerated configurations
  • Data analytics and business intelligence data processing for mid-market enterprises
  • Scientific research compute node for academic and industrial R&D facilities
  • High-definition visualization and rendering workstations for creative services departments

Technical specifications

ManufacturerHPE
ModelProLiant ML350 Gen11 Tower Server
ManufacturerPartNumberP53566-B21
FormFactorTower
ProcessorSockets2
ProcessorFamilyAMD EPYC 8004 Series (Genoa, 3rd-gen EPYC)
ProcessorCoresPerSocket12–16 cores (dependent on SKU)
MaxMemoryCapacity4 TB (32 DIMM slots, 128 GB per DIMM)
MemoryTypeDDR5 RDIMM ECC
MemorySpeed5600 MHz
StorageExpansion8× 3.5-inch SAS/SATA hot-swap bays or 6× 2.5-inch SFF bays
RAIDControllerSmart Array E208i-p SR Gen11 (integrated)
PCIExpansion3× PCIe 5.0 slots, 1× PCIe 4.0 slot
NetworkInterfaces2× 1-GbE RJ-45 (integrated); expansion options via daughter card
ManagementInterfaceIPMI 2.0, Redfish, iLO 6
PowerSupply2× hot-plug 800W 80+ Platinum (configurable)
ThermalDesignTool-less PSU and drive removal, side-access memory/expansion
LaunchedQ3 2023

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandHPE
CategoryServers
SKUP53566-B21
Part NumberP53566-B21
ConditionNew
ModelProLiant ML350 Gen11 Tower Server
ManufacturerPartNumberP53566-B21
FormFactorTower
ProcessorSockets2
ProcessorFamilyAMD EPYC 8004 Series (Genoa, 3rd-gen EPYC)
ProcessorCoresPerSocket12–16 cores (dependent on SKU)
MaxMemoryCapacity4 TB (32 DIMM slots, 128 GB per DIMM)
MemoryTypeDDR5 RDIMM ECC
MemorySpeed5600 MHz
StorageExpansion8× 3.5-inch SAS/SATA hot-swap bays or 6× 2.5-inch SFF bays
RAIDControllerSmart Array E208i-p SR Gen11 (integrated)
PCIExpansion3× PCIe 5.0 slots, 1× PCIe 4.0 slot
NetworkInterfaces2× 1-GbE RJ-45 (integrated); expansion options via daughter card
ManagementInterfaceIPMI 2.0, Redfish, iLO 6
PowerSupply2× hot-plug 800W 80+ Platinum (configurable)
ThermalDesignTool-less PSU and drive removal, side-access memory/expansion
LaunchedQ3 2023

Frequently Asked Questions about HPE ProLiant ML350 Gen11 Tower Server

What does the HPE ProLiant ML350 Gen11 Tower Server do?

The HPE ProLiant ML350 Gen11 Tower Server is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.

What are the headline specs of the HPE ProLiant ML350 Gen11 Tower Server?

Key specifications for the HPE ProLiant ML350 Gen11 Tower Server: new condition; manufacturer HPE; model ProLiant ML350 Gen11 Tower Server; manufacturerpartnumber P53566-B21; formfactor Tower; processorsockets 2; processorfamily AMD EPYC 8004 Series (Genoa, 3rd-gen EPYC). Manufacturer part number P53566-B21. For the full datasheet with electrical, environmental, and compliance details, contact our pre-sales engineering team.