HPE ProLiant DL385 Gen11 Server
Brand: HPE | Category: Servers
SKU: HP-P55244B21 | Part #: P55244-B21 | MPN: P55244-B21
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About the HPE ProLiant DL385 Gen11 Server
The HPE ProLiant DL385 Gen11 is a 2U, dual-socket server built on the AMD EPYC 9004-series (Genoa) architecture, delivering up to 192 cores per system with exceptional compute density. The platform features PCIe 5.0 I/O connectivity, support for up to 12 TB of DDR5 memory, and 12 NVMe SSD bays, enabling organizations to consolidate workloads with substantial performance-per-watt efficiency. The Gen11 architecture introduces enhanced memory bandwidth, improved cache hierarchies, and advanced security features including AMD SEV-SNP for confidential computing.
Designed for organizations migrating from x86 incumbents to high-core-count AMD platforms, the DL385 Gen11 excels in virtualized environments, containerized deployments, and compute-intensive HPC clusters. HPE's integrated management stack—including iLO6 out-of-band management, OneView integration, and Redfish API support—provides consistent lifecycle automation across heterogeneous infrastructure. The server supports hot-pluggable components, redundant power supplies, and modular storage configurations, minimizing downtime and simplifying operational scaling.
Enterprise demand for the DL385 Gen11 reflects the broader industry shift toward AMD EPYC platforms for density-optimized deployments. The server's thermal efficiency, per-core scalability, and ecosystem compatibility with popular hypervisors (VMware vSphere, KVM, Hyper-V) and container orchestration platforms (Kubernetes, Docker) position it as a foundational building block for cloud-native and HPC-adjacent data centers.
Ideal for
- Large-scale virtualization clusters consolidating hundreds of VMs with reduced infrastructure footprint and power consumption
- High-performance computing (HPC) workloads including scientific simulation, molecular dynamics, and finite-element analysis leveraging multi-core parallelism
- In-memory big data analytics and machine learning inference using Apache Spark, TensorFlow, or PyTorch on DDR5-backed NUMA systems
- Containerized microservices platforms running Kubernetes at scale with substantial per-node resource density for cost optimization
- Database workloads (SQL Server, PostgreSQL, MySQL) benefiting from high core counts, memory bandwidth, and PCIe 5.0 storage connectivity
- Content delivery and media processing pipelines requiring sustained multi-threaded throughput across distributed encoding or transcoding farms
Technical specifications
| Manufacturer | HP |
| Model | ProLiant DL385 Gen11 |
| Form Factor | 2U, dual-socket |
| Processor Socket | AMD EPYC 9004-series (SP6 socket) |
| Max Processor Count | 2 |
| Max Cores (Single Config) | 192 (2× 96-core Genoa) |
| Max Memory Capacity | 12 TB |
| Memory Type | DDR5, registered DIMM (RDIMM) |
| Memory Speed | Up to 5600 MT/s |
| Memory Slots | 12 slots per socket (24 total) |
| Storage Bays | 12× 2.5-inch NVMe/SSD hot-plug bays |
| I/O Standard | PCIe 5.0 (16 lanes per slot, dual-slot GPU support available) |
| Network | 4× 10GbE RJ45 on-board (LOM); additional slots for expansion NICs |
| Power Supply | Redundant hot-plug (2×1600W or 2×2000W options) |
| Management Interface | HPE iLO6 (out-of-band Ethernet) |
| Security Features | AMD SEV-SNP, TPM 2.0, secure boot, UEFI firmware |
| Thermal Design | High-performance cooling with modular fans; support for 10–35°C ambient |
| Launch Timeline | Q3 2023 |
| Supported Hypervisors | VMware vSphere, KVM, Microsoft Hyper-V, Citrix XenServer |
| Certifications | ISO 9001, RoHS 3, CE marking, FCC compliance |
Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.
Technical Specifications
| Brand | HPE |
| Category | Servers |
| SKU | HP-P55244B21 |
| Part Number | P55244-B21 |
| Condition | New |
| Model | ProLiant DL385 Gen11 |
| Form Factor | 2U, dual-socket |
| Processor Socket | AMD EPYC 9004-series (SP6 socket) |
| Max Processor Count | 2 |
| Max Cores (Single Config) | 192 (2× 96-core Genoa) |
| Max Memory Capacity | 12 TB |
| Memory Type | DDR5, registered DIMM (RDIMM) |
| Memory Speed | Up to 5600 MT/s |
| Memory Slots | 12 slots per socket (24 total) |
| Storage Bays | 12× 2.5-inch NVMe/SSD hot-plug bays |
| I/O Standard | PCIe 5.0 (16 lanes per slot, dual-slot GPU support available) |
| Network | 4× 10GbE RJ45 on-board (LOM); additional slots for expansion NICs |
| Power Supply | Redundant hot-plug (2×1600W or 2×2000W options) |
| Management Interface | HPE iLO6 (out-of-band Ethernet) |
| Security Features | AMD SEV-SNP, TPM 2.0, secure boot, UEFI firmware |
| Thermal Design | High-performance cooling with modular fans; support for 10–35°C ambient |
| Launch Timeline | Q3 2023 |
| Supported Hypervisors | VMware vSphere, KVM, Microsoft Hyper-V, Citrix XenServer |
| Certifications | ISO 9001, RoHS 3, CE marking, FCC compliance |
Frequently Asked Questions about HPE ProLiant DL385 Gen11 Server
What does the HPE ProLiant DL385 Gen11 Server do?
The HPE ProLiant DL385 Gen11 Server is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.
What are the headline specs of the HPE ProLiant DL385 Gen11 Server?
Key specifications for the HPE ProLiant DL385 Gen11 Server: new condition; manufacturer HP; model ProLiant DL385 Gen11; form factor 2U, dual-socket; processor socket AMD EPYC 9004-series (SP6 socket); max processor count 2; max cores (single config) 192 (2× 96-core Genoa). Manufacturer part number P55244-B21. For the full datasheet with electrical, environmental, and compliance details, contact our pre-sales engineering team.