HPE ProLiant Compute XD685 (AMD MI325X)

HPE ProLiant Compute XD685 (AMD MI325X)

Brand: HPE | Category: Servers

SKU: HP-P65818B21 | Part #: P65818-B21 | MPN: P65818-B21

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About the HPE ProLiant Compute XD685 (AMD MI325X)

The HPE ProLiant Compute XD685 is a 4U GPU-optimized server designed from the ground up for demanding AI training, large language model development, and high-performance computing workloads. It houses eight AMD Instinct MI325X accelerators, each equipped with 256 GB of HBM3E memory, delivering a combined 2 TB of GPU-addressable high-bandwidth memory within a single node. The platform leverages AMD ROCm software stack compatibility, enabling seamless integration with popular AI frameworks including PyTorch, TensorFlow, and JAX, while the high-bandwidth GPU interconnect fabric based on AMD Infinity Fabric ensures low-latency peer-to-peer communication between all eight accelerators without CPU bottlenecking.

Ideal for

  • Large language model (LLM) and foundation model pre-training requiring multi-terabyte GPU memory capacity across distributed node clusters
  • Generative AI fine-tuning and reinforcement learning from human feedback (RLHF) pipelines demanding high GPU memory bandwidth per node
  • Computational fluid dynamics, molecular dynamics, and physics-based HPC simulations leveraging AMD ROCm GPU compute
  • Multi-modal AI model training combining vision, language, and audio datasets at enterprise research scale
  • AI inference serving for very large models that exceed single-GPU memory capacity, utilizing NVMe-over-Fabric or high-bandwidth storage tiers
  • Financial risk modeling, seismic processing, and climate simulation workloads that benefit from FP64 and FP32 mixed-precision GPU throughput

Technical specifications

ManufacturerHP (Hewlett Packard Enterprise)
Product LineHPE ProLiant Compute XD685
Form Factor4U Rack Server
ProcessorDual AMD EPYC 9004-series (Genoa/Bergamo architecture), up to 96 cores per socket
Total CPU CoresUp to 192 cores (2 sockets)
System Memory TypeDDR5 RDIMM / 3DS RDIMM
System Memory Slots24 x DIMM slots (12 per CPU)
Maximum System MemoryUp to 3 TB DDR5
GPU Accelerators8 x AMD Instinct MI325X
GPU Memory per Accelerator256 GB HBM3E
Total GPU Memory2 TB HBM3E aggregate
GPU InterconnectAMD Infinity Fabric (peer-to-peer GPU interconnect)
Peak GPU FP8 PerformanceApprox. 7,936 TFLOPS aggregate (8x ~992 TFLOPS per MI325X)
Peak GPU FP16/BF16 PerformanceApprox. 3,968 TFLOPS aggregate
PCIe GenerationPCIe Gen 5
Network ConnectivityMultiple PCIe Gen 5 slots supporting up to 400 GbE NIC or InfiniBand NDR HCA
StorageFront-accessible NVMe SSD bays (OS boot + optional NVMe data storage)
Power SupplyRedundant hot-plug Titanium-rated PSUs (total system power up to ~10 kW configuration)
CoolingHigh-density forced-air cooling with optional direct liquid cooling (DLC) support
ManagementHPE iLO 6 (Integrated Lights-Out 6) with HPE GreenLake integration
Operating System SupportRed Hat Enterprise Linux, SUSE Linux Enterprise Server, Ubuntu Server LTS
AI Software StackAMD ROCm (compatible with PyTorch, TensorFlow, JAX, OpenCL)
Security FeaturesHPE Silicon Root of Trust, Secure Boot, BIOS firmware signing, iLO 6 hardware-enforced security
Chassis Dimensions4U standard EIA-310 rack form factor
Launch Generation2025 Q2

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandHPE
CategoryServers
SKUHP-P65818B21
Part NumberP65818-B21
ConditionNew
Product LineHPE ProLiant Compute XD685
Form Factor4U Rack Server
ProcessorDual AMD EPYC 9004-series (Genoa/Bergamo architecture), up to 96 cores per socket
Total CPU CoresUp to 192 cores (2 sockets)
System Memory TypeDDR5 RDIMM / 3DS RDIMM
System Memory Slots24 x DIMM slots (12 per CPU)
Maximum System MemoryUp to 3 TB DDR5
GPU Accelerators8 x AMD Instinct MI325X
GPU Memory per Accelerator256 GB HBM3E
Total GPU Memory2 TB HBM3E aggregate
GPU InterconnectAMD Infinity Fabric (peer-to-peer GPU interconnect)
Peak GPU FP8 PerformanceApprox. 7,936 TFLOPS aggregate (8x ~992 TFLOPS per MI325X)
Peak GPU FP16/BF16 PerformanceApprox. 3,968 TFLOPS aggregate
PCIe GenerationPCIe Gen 5
Network ConnectivityMultiple PCIe Gen 5 slots supporting up to 400 GbE NIC or InfiniBand NDR HCA
StorageFront-accessible NVMe SSD bays (OS boot + optional NVMe data storage)
Power SupplyRedundant hot-plug Titanium-rated PSUs (total system power up to ~10 kW configuration)
CoolingHigh-density forced-air cooling with optional direct liquid cooling (DLC) support
ManagementHPE iLO 6 (Integrated Lights-Out 6) with HPE GreenLake integration
Operating System SupportRed Hat Enterprise Linux, SUSE Linux Enterprise Server, Ubuntu Server LTS
AI Software StackAMD ROCm (compatible with PyTorch, TensorFlow, JAX, OpenCL)
Security FeaturesHPE Silicon Root of Trust, Secure Boot, BIOS firmware signing, iLO 6 hardware-enforced security
Chassis Dimensions4U standard EIA-310 rack form factor
Launch Generation2025 Q2

Frequently Asked Questions about HPE ProLiant Compute XD685 (AMD MI325X)

What does the HPE ProLiant Compute XD685 (AMD MI325X) do?

The HPE ProLiant Compute XD685 (AMD MI325X) is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.

What are the headline specs of the HPE ProLiant Compute XD685 (AMD MI325X)?

Key specifications for the HPE ProLiant Compute XD685 (AMD MI325X): new condition; manufacturer HP (Hewlett Packard Enterprise); product line HPE ProLiant Compute XD685; form factor 4U Rack Server; processor Dual AMD EPYC 9004-series (Genoa/Bergamo architecture), up to 96 cores per socket; total cpu cores Up to 192 cores (2 sockets); system memory type DDR5 RDIMM / 3DS RDIMM. Manufacturer part number P65818-B21. For the full datasheet with electrical, environmental, and compliance details, contact our pre-sales engineering team.