HPE ProLiant Compute XD220 Server

HPE ProLiant Compute XD220 Server

Brand: HPE | Category: Servers

SKU: HP-S2K20A | Part #: S2K20A | MPN: S2K20A

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About the HPE ProLiant Compute XD220 Server

The HPE ProLiant Compute XD220 Server (S2K20A) is a high-density, single-socket compute node engineered specifically for scale-out HPC environments, AI inference at the edge, and large-scale modeling and simulation clusters. Built on HPE's XD (Extreme Density) architecture, it slots into HPE's multi-node chassis infrastructure, delivering exceptional compute density without compromising individual node manageability or performance. The node supports AMD EPYC processors and is optimized to maximize core counts and memory bandwidth within a thermally and mechanically constrained high-density form factor.

The XD220 is designed to be deployed in large quantities within HPE's ProLiant XD chassis, enabling organizations to build tightly coupled compute clusters with reduced cabling overhead, simplified rack management, and centralized power and cooling infrastructure. Each node maintains independent identity and management through HPE iLO, preserving granular monitoring and firmware control at the node level even within a shared chassis environment. This architecture is particularly well suited to workloads that require many parallel, independent compute tasks running simultaneously across dozens or hundreds of nodes.

Target deployments include university research computing centers, national laboratories, financial risk modeling farms, computational fluid dynamics pipelines, seismic processing environments, and enterprise AI/ML training and inference infrastructure. The ProLiant Compute XD220 is a component of HPE's broader high-performance computing portfolio and is supported under HPE's standard enterprise support services framework, integrating with HPE OneView and HPE Insight Cluster Management Utility for orchestration at scale.

Ideal for

  • High-performance computing (HPC) cluster deployments requiring maximum compute node density per rack unit in research or national laboratory environments
  • Large-scale computational fluid dynamics (CFD) and finite element analysis (FEA) modeling and simulation workloads in engineering and manufacturing
  • Seismic data processing and geophysical modeling for energy sector exploration pipelines
  • Financial services Monte Carlo simulation and risk modeling farms demanding high parallel throughput across many independent compute tasks
  • AI and machine learning inference infrastructure where many parallel single-socket nodes provide cost-effective throughput at scale
  • University and academic research computing centers building shared HPC resources for multi-tenant scientific workloads

Technical specifications

ManufacturerHP
Manufacturer Part NumberS2K20A
Product LineHPE ProLiant XD
Form FactorHigh-density multi-node compute node
Chassis CompatibilityHPE ProLiant XD chassis
Processor Socket1 x AMD EPYC (single-socket)
Processor FamilyAMD EPYC 9004 Series (Genoa)
Maximum Processor CoresUp to 96 cores per node (processor-dependent)
Memory TypeDDR5
Memory Slots12 x DIMM slots per node
Maximum Memory1.5TB DDR5 per node
Storage SupportNVMe SSD via M.2 or front-accessible drive bays
NetworkIntegrated high-speed fabric connectivity via chassis midplane
ManagementHPE Integrated Lights-Out (iLO) per node
Software IntegrationHPE OneView, HPE Insight Cluster Management Utility (CMU)
Operating System SupportRHEL, SLES, Ubuntu, Windows Server (selected versions)
PowerShared chassis power infrastructure with per-node power management
SecurityHPE Silicon Root of Trust, secure boot, node-level firmware integrity

Available from Omnixon Global. Submit an RFQ and our team will confirm configuration and availability for your order.

Technical Specifications

BrandHPE
CategoryServers
SKUHP-S2K20A
Part NumberS2K20A
ConditionNew
Manufacturer Part NumberS2K20A
Product LineHPE ProLiant XD
Form FactorHigh-density multi-node compute node
Chassis CompatibilityHPE ProLiant XD chassis
Processor Socket1 x AMD EPYC (single-socket)
Processor FamilyAMD EPYC 9004 Series (Genoa)
Maximum Processor CoresUp to 96 cores per node (processor-dependent)
Memory TypeDDR5
Memory Slots12 x DIMM slots per node
Maximum Memory1.5TB DDR5 per node
Storage SupportNVMe SSD via M.2 or front-accessible drive bays
NetworkIntegrated high-speed fabric connectivity via chassis midplane
ManagementHPE Integrated Lights-Out (iLO) per node
Software IntegrationHPE OneView, HPE Insight Cluster Management Utility (CMU)
Operating System SupportRHEL, SLES, Ubuntu, Windows Server (selected versions)
PowerShared chassis power infrastructure with per-node power management
SecurityHPE Silicon Root of Trust, secure boot, node-level firmware integrity

Frequently Asked Questions about HPE ProLiant Compute XD220 Server

What does the HPE ProLiant Compute XD220 Server do?

The HPE ProLiant Compute XD220 Server is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.

What are the headline specs of the HPE ProLiant Compute XD220 Server?

Key specifications for the HPE ProLiant Compute XD220 Server: new condition; manufacturer HP; manufacturer part number S2K20A; product line HPE ProLiant XD; form factor High-density multi-node compute node; chassis compatibility HPE ProLiant XD chassis; processor socket 1 x AMD EPYC (single-socket). Manufacturer part number S2K20A. For the full datasheet with electrical, environmental, and compliance details, contact our pre-sales engineering team.