HPE ProLiant DL380 Gen12 GPU Computing Server

Brand: HP | Category: Servers

SKU: HP-P77372B21 | Part #: P77372-B21 | MPN: P77372-B21

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About the HPE ProLiant DL380 Gen12 GPU Computing Server

The HPE ProLiant DL380 Gen12 GPU Computing Server from HP is enterprise-grade Servers hardware built for data centers. HPE ProLiant DL380 Gen12 GPU Computing Server delivers PCIe Gen5 acceleration for up to four double-wide GPUs, purpose-built for enterprise AI training and inferencing at scale. Available in brand new condition. Available from Omnixon Global — contact our team to request a quote.

Technical Specifications

BrandHP
CategoryServers
SKUHP-P77372B21
Part NumberP77372-B21
ConditionNew
Product LineHPE ProLiant DL380 Gen12
Form Factor2U Rack Server
Processor Sockets2x Socket SP5 (AMD EPYC 9004/9005 series) or 2x LGA4677 (Intel Xeon Scalable 6th Gen)
Max Processor TDP SupportUp to 400W TDP per processor
Memory Slots32x DDR5 RDIMM / LRDIMM slots
Maximum Memory Capacity6TB DDR5 ECC Registered
Memory SpeedUp to DDR5-5600 MHz
GPU Accelerator SlotsUp to 4x double-wide GPU accelerators (NVIDIA H100/H200 SXM or PCIe, AMD Instinct MI300X compatible)
PCIe GenerationPCIe Gen5 (x16 per GPU riser slot)
GPU Riser ConfigurationDedicated PCIe Gen5 GPU risers with 128 GB/s bidirectional bandwidth per slot
Power SupplyDual 1600W Platinum HPE Flex Slot Power Supplies (N+1 redundant, hot-plug)
Power Efficiency Rating80 PLUS Platinum (≥94% efficiency at 50% load)
Storage BaysUp to 12x 3.5-inch LFF or 24x 2.5-inch SFF SAS/SATA/NVMe hot-plug drive bays
NVMe SupportFront-facing NVMe U.3/U.2 drives via PCIe Gen5 NVMe backplane
Network Ports4x 25GbE onboard (Intel E810 or Broadcom BCM57504); expandable via OCP 3.0 mezzanine slot to 100GbE/400GbE
Management ControllerHPE iLO 6 with dedicated 1GbE management port, GPU telemetry, and HPE GreenLake integration
Cooling ArchitectureN+1 high-static-pressure hot-plug fans with GPU-dedicated thermal zones and predictive thermal control via iLO 6
RAID SupportHPE Smart Array Gen11 controller supporting RAID 0/1/5/6/10/50/60; optional HPE NS204i-u NVMe RAID
Operating System SupportRed Hat Enterprise Linux, SUSE Linux Enterprise Server, Ubuntu Server, VMware vSphere 8, Windows Server 2025
Security FeaturesHPE Silicon Root of Trust, Secure Boot, TPM 2.0, iLO Amplifier Pack integration, FIPS 140-2 compliant firmware
Chassis Dimensions2U (86.8mm H x 447mm W x 800mm D)
Launch Quarter2025-Q3

Frequently Asked Questions about HPE ProLiant DL380 Gen12 GPU Computing Server

What does the HPE ProLiant DL380 Gen12 GPU Computing Server do?

The HPE ProLiant DL380 Gen12 GPU Computing Server is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.

What are the headline specs of the HPE ProLiant DL380 Gen12 GPU Computing Server?

Key specifications for the HPE ProLiant DL380 Gen12 GPU Computing Server: new condition; manufacturer HP (Hewlett Packard Enterprise); product line HPE ProLiant DL380 Gen12; form factor 2U Rack Server; processor sockets 2x Socket SP5 (AMD EPYC 9004/9005 series) or 2x LGA4677 (Intel Xeon Scalable 6th Gen); max processor tdp support Up to 400W TDP per processor; memory slots 32x DDR5 RDIMM / LRDIMM slots. Manufacturer part number P77372-B21. For the full datasheet with electrical, environmental, and compliance details, contact our pre-sales engineering team.