HPE ProLiant Compute XD685 Gen12

Brand: HP | Category: Servers

SKU: HP-P75320B21 | Part #: P75320-B21 | MPN: P75320-B21

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About the HPE ProLiant Compute XD685 Gen12

The HPE ProLiant Compute XD685 Gen12 from HP is enterprise-grade Servers hardware built for data centers. Dense 5U AI training powerhouse engineered for large-scale generative AI clusters with 8 AMD Instinct MI325X accelerators. Available in brand new condition. Available from Omnixon Global — contact our team to request a quote.

Technical Specifications

BrandHP
CategoryServers
SKUHP-P75320B21
Part NumberP75320-B21
ConditionNew
Product LineHPE ProLiant Compute XD685 Gen12
Form Factor5U Rack-Mount
CPU ArchitectureAMD EPYC Gen5 (Zen 5) dual-socket
Max CPU CoresUp to 256 total cores (2x 128-core EPYC processors)
GPU Accelerators Supported8x AMD Instinct MI325X per node
GPU InterconnectAMD Infinity Fabric (XGMI) high-bandwidth GPU-to-GPU fabric
Accelerator MemoryUp to 1,536 GB HBM3 total (8x 192 GB per MI325X)
System Memory TypeDDR5 ECC Registered DIMMs
System Memory CapacityUp to 6 TB DDR5 across 24 DIMM slots per socket
PCIe GenerationPCIe Gen 5.0 x16 per accelerator slot
Internal StorageUp to 8x NVMe U.2/E3.S Gen5 drives for dataset staging and checkpoint storage
Network Interface OptionsDual 400GbE OSFP / InfiniBand NDR 400 Gb/s per node (OCP 3.0 NIC slots)
Power SupplyRedundant 80 PLUS Titanium PSUs, N+1 hot-plug configuration
Max System PowerUp to 10 kW per node (configured with 8x MI325X at TDP)
CoolingHigh-volume hot-plug fan modules with rear-exhaust airflow optimized for GPU thermal dissipation
Management ControllerHPE iLO 7 BMC with Redfish API, IPMI 2.0, integrated GPU telemetry and predictive analytics
Management Software IntegrationHPE GreenLake for HPC & AI, HPE Cray ClusterStor compatible, Slurm and Kubernetes operator support
OS SupportRed Hat Enterprise Linux, SUSE Linux Enterprise Server, Ubuntu Server LTS, ROCm software stack natively supported
Security FeaturesHPE Silicon Root of Trust, Secure Boot, UEFI firmware signed validation, iLO Advanced security controls
Rack Units5U
Launch GenerationGen12 (2025-Q4)

Frequently Asked Questions about HPE ProLiant Compute XD685 Gen12

What does the HPE ProLiant Compute XD685 Gen12 do?

The HPE ProLiant Compute XD685 Gen12 is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.

What are the headline specs of the HPE ProLiant Compute XD685 Gen12?

Key specifications for the HPE ProLiant Compute XD685 Gen12: new condition; manufacturer HP (Hewlett Packard Enterprise); product line HPE ProLiant Compute XD685 Gen12; form factor 5U Rack-Mount; cpu architecture AMD EPYC Gen5 (Zen 5) dual-socket; max cpu cores Up to 256 total cores (2x 128-core EPYC processors); gpu accelerators supported 8x AMD Instinct MI325X per node. Manufacturer part number P75320-B21. For the full datasheet with electrical, environmental, and compliance details, contact our pre-sales engineering team.