HPE OmniStack HCI 380 Gen12
Brand: HP | Category: Servers
SKU: P77080-B21 | Part #: P77080-B21 | MPN: P77080-B21
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About the HPE OmniStack HCI 380 Gen12
The HPE OmniStack HCI 380 Gen12 (part number P77080-B21) features integrated HPE FlexibleLOM network interfaces supporting 10/25/100GbE configurations, with PCIe Gen5 expansion slots for high-speed connectivity and storage acceleration. This 2U rack server leverages dual Intel Xeon Scalable (6th Generation) processor sockets and combines hyperconverged infrastructure with dedicated data services offload via the HPE OmniStack Accelerator Card, enabling always-on inline deduplication and compression across the full data path. Storage flexibility is delivered through NVMe and SAS/SATA hybrid support, allowing enterprises to optimize performance and cost within a single platform.
Built on the proven HP ProLiant DL380 Gen12 chassis, the HPE OmniStack HCI 380 Gen12 runs HPE SimpliVity OmniStack hyperconverged software with VMware vSphere (ESXi) hypervisor support and scale-out federation capabilities that enable multiple nodes to be managed as a single resource pool. Management is streamlined through HPE iLO 7, VMware vCenter Plugin integration, and HPE GreenLake connectivity, while redundant hot-plug power supplies ensure continuous operation. Storage architects and IT procurement teams evaluating converged infrastructure solutions will find this system purpose-built for enterprise workloads requiring proven data efficiency and operational simplicity.
Typical Enterprise Deployments
- Virtual desktop infrastructure (VDI) with real-time deduplication reducing storage footprint across pooled user environments
- Private cloud and multi-tenant data center expansion using scale-out federation across clustered nodes
- Production databases and business-critical applications leveraging dual Xeon processors and hybrid NVMe/SAS storage tiers
- Disaster recovery and backup consolidation with always-on compression minimizing bandwidth and storage costs
- Mixed workload environments combining high-performance NVMe tiers with cost-optimized SAS/SATA capacity in a single 2U form factor
Contact Omnixon Global to request a quotation and discuss licensing, configuration, and delivery options for the HPE OmniStack HCI 380 Gen12 (P77080-B21).
Technical Specifications
| Brand | HP |
| Category | Servers |
| SKU | P77080-B21 |
| Part Number | P77080-B21 |
| Condition | New |
| Manufacturer Part Number | P77080-B21 |
| Product Line | HPE OmniStack HCI (SimpliVity) |
| Base Platform | HPE ProLiant DL380 Gen12 |
| Form Factor | 2U Rack Server |
| Processor Family | Intel Xeon Scalable (6th Generation) |
| Processor Sockets | 2 |
| Hyperconverged Software | HPE SimpliVity OmniStack |
| Data Services | Always-on inline deduplication and compression (full data path) |
| Data Offload | HPE OmniStack Accelerator Card (dedicated data services offload) |
| Storage Interface | NVMe and SAS/SATA hybrid support |
| PCIe Generation | PCIe Gen5 |
| Network Interface | Integrated HPE FlexibleLOM; supports 10/25/100GbE configurations |
| Management Software | HPE iLO 7, VMware vCenter Plugin, HPE GreenLake integration |
| Hypervisor Support | VMware vSphere (ESXi) |
| Cluster Scalability | Scale-out federation; multiple nodes managed as a single resource pool |
| Rack Units | 2U |
| Power Supply | Redundant hot-plug power supplies |
| Chassis Standard | HPE ProLiant DL380 Gen12 chassis |
Frequently Asked Questions about HPE OmniStack HCI 380 Gen12
What does the HPE OmniStack HCI 380 Gen12 do?
The HPE OmniStack HCI 380 Gen12 is built for enterprise data-center workloads — virtualization (VMware, Proxmox, Nutanix), private cloud, database hosting, and AI/ML training. It fits standard EIA-310 server racks and supports redundant PSUs and hot-swap drives common in production environments.